Psoriasis is a chronic autoimmune skin disorder that results from hyperproliferation of keratinocytes and recruitment of inflammatory cells. Therefore, work has been done to develop a strategy aimed at mitigating this disease by encouraging programmed cell death of keratinocytes to limit the spread of the disease. Therefore, a nanocomposite was designed that is able to treat psoriasis using this strategy, in addition to raising the temperature by absorbing near-infrared radiation. To this end, bacilli were loaded with gold nanoparticles and isatin, an anti-inflammatory drug that helps act as an anticonvulsant For psoriasis, in a poly(lactic-co-glycolic acid) matrix to produce nanocomposites. The physical, chemical and photothermal properties of the produced nanocomposites were studied. A study of the effect of the prepared compound on live mice showed that the embedded nanocomposites and near-infrared light prevent epidermal hyperplasia and limit the spread of the disease. The study also showed that the nanocomposites continued to be active in the skin for at least 5 days. It also showed minimal toxicity in the skin or liver of healthy mice.
Research paper link:https://doi.org/10.1016/j.jconrel.2021.04.005